"WE just want him home," Alanvale mother Lillian Watkins says of her son Christopher Dean Watkins, who was last seen about 12 days ago.
Mr Watkins, 28, was reported missing to police on Saturday.
He had been staying with friends at Mayfield.
Mrs Watkins said she did not know what had happened to her eldest son.
"It's just out of character for him not to be in contact with his two brothers," she said.
"They are very close. His family is missing him.
"I got concerned myself on Monday last week when I knew that he did not access his bank account, but his brother Sean had concerns before that.
"I just want him to come home or make contact with me or Sean or his dad Ray, just to let us know that he is OK, or if there is a particular reason why he has gone away for a while.
"Please contact us and let us know you're OK."
Mr Watkins is about 170 centimetres tall, of medium build, with a bald head, blue eyes and tattoos.
Police urge anyone with information about his whereabouts to call Launceston police on 63363701 or Crime Stoppers on 1800333000.
Christopher Dean Watkins: Tasmanian Police offer $50,000 reward in case of missing Launceston man
Police are offering a $50,000 reward for information that helps them solve the case of the disappearance of a Launceston man two years ago.
Christopher Dean Watkins, 28, was last seen at a unit in Box Street, Mayfield, on August 7, 2013 and police now strongly suspect he was murdered.
Tasmania Police Detective Inspector John King said Mr Watkins made a panicked phone call to a family member after two men he had a troubled history with visited the Mayfield home he shared with four other men.
Detective Inspector King said all six men are believed to have misled police about what happened to Mr Watkins.
"All the people who were living at that address, and the two people who visited, are definitely persons of interest for murder," he said.
"If they weren't involved in the murder, they were involved in perverting the course of justice."
He said the reward may encourage people who have information about the case to come forward.
"There are people out there who know what happened and who know who is responsible," he said.
"We're anticipating that with the passage of time and the inducement of this reward there will be people who may reconsider their choice to remain silent."
National Missing Persons Week begins on Sunday with the theme "follow your instincts".
Police said it was a myth that people had to wait for 24 hours before they can report someone as missing.
Police ask anyone who has information on any of these cases to contact them on 131 444 or Crime Stoppers or anonymously 1800 333 000.
Men charged with conspiracy over investigation into missing man Christopher Watkins
TWO men have been charged in connection with the disappearance and suspected murder of Launceston man Christopher Dean Watkins.
The two men, both from Launceston, have been charged with conspiracy.
Police allege the men, aged 22 and 23, conspired to pervert the due course of justice by deliberately providing false information during the police investigation.
Mr Watkins was last sighted in Mayfield on the evening of August 7, 2013.
His disappearance has been the subject of an intensive police investigation since he went missing.
A $50,000 reward was offered last week for information leading to a prosecution in the case.
“Both these men are alleged to have been living at the address at which Mr Watkins was last seen,” Northern CIB Detective Inspector John King said.
“We allege that they have provided false information about the events of that night.
“Investigations are ongoing and we anticipate additional charges against others as more information comes to hand.”
Woman convicted over false statement in suspected Launceston murder case
your age and circumstances should assume greater importance than general deterrence.”